Congratulations to lab member Ryan Passino on successfully defending his dissertation entitled “Immune-Mediated Retinal Ganglion Cell Axon Regeneration: The Role of Neutrophil-Induced Vascular Damage and Microglial Protection.”
Congratulations to lab member Hannah Hafner for receiving a top 5% score on the F31 Ruth Kirschstein Fellowship!
Congratulations to lab member Mitre Athaiya for winning Best Poster Award at the Gordon Research Conference on Central Nervous System Injury and Repair!
New Publication!
Like all receptor tyrosine kinases (RTKs), ErbB4 signals through a canonical signaling involving phosphorylation cascades. However, ErbB4 can also signal through a non‑canonical mechanism whereby the intracellular domain is released into the cytoplasm by regulated intramembrane proteolysis (RIP) and translocates to the nucleus where it regulates transcription. These different signaling mechanisms depend on the generation of alternative spliced isoforms, a RIP cleavable ErbB4‑ JMa and…
New Publication from the Giger lab!
Hedgehog signaling controls tissue patterning during embryonic and postnatal development and continues to play important roles throughout life. Characterizing the full complement of Hedgehog pathway components is essential to understanding its wide-ranging functions. Previous work has identified neuropilins, established semaphorin receptors, as positive regulators of Hedgehog signaling. Neuropilins require plexin co-receptors to mediate semaphorin signaling, but the role of plexins in Hedgehog signaling has not…
Congratulations to Dr. Ligia Buloto-Schmitd on her TEAM T32 Training Grant Re-appointment!
The Giger laboratory is extremely proud of Dr. Ligia Buloto-Schmitd on her re-appointment with the NIH TEAM T32 Training Grant. This opportunity will support Ligia in a variety of ways to continue the important research that she is currently conducting in the laboratory. Job well-done, Dr. Buloto-Schmitd!
Welcome to the lab, Ayo and Fanny!
The Giger Lab welcomes two postdoctoral scholars, Ayobami (Ayo) and Qian (Fanny) starting summer of 2022. Welcome to the lab, Ayo and Fanny! We look forward to working with you.
New Publication! Click here for more info.
Abstract During mammalian neocortex development, nascent pyramidal neurons migrate along radial glial cells and overtake earlier-born neurons to terminate at the front of the developing cortical plate (CP), leading to the outward expansion of the CP border. While much has been learned about the cellular and molecular mechanisms that underlie the migration of pyramidal neurons, how migrating neurons bypass the preceding neurons at the end…
Cell and Departmental Biology Seminar Series: Giger Lab
Please join us on Wednesday, May 4th, at 9:30 AM (Forum Hall, Palmer Commons) as the Giger lab presents the weekly CDB departmental seminar. Giger Lab members will speak on the topic below: Building, breaking down, and re-building the nervous system.