Like all receptor tyrosine kinases (RTKs), ErbB4 signals through a canonical signaling involving phosphorylation cascades. However, ErbB4 can also signal through a non‑canonical mechanism whereby the intracellular domain is released into the cytoplasm by regulated intramembrane proteolysis (RIP) and translocates to the nucleus where it regulates transcription. These different signaling mechanisms depend on the generation of alternative spliced isoforms, a RIP cleavable ErbB4‑ JMa and…
Hedgehog signaling controls tissue patterning during embryonic and postnatal development and continues to play important roles throughout life. Characterizing the full complement of Hedgehog pathway components is essential to understanding its wide-ranging functions. Previous work has identified neuropilins, established semaphorin receptors, as positive regulators of Hedgehog signaling. Neuropilins require plexin co-receptors to mediate semaphorin signaling, but the role of plexins in Hedgehog signaling has not…
The Giger laboratory is extremely proud of Dr. Ligia Buloto-Schmitd on her re-appointment with the NIH TEAM T32 Training Grant. This opportunity will support Ligia in a variety of ways to continue the important research that she is currently conducting in the laboratory. Job well-done, Dr. Buloto-Schmitd!
The Giger Lab welcomes two postdoctoral scholars, Ayobami (Ayo) and Qian (Fanny) starting summer of 2022. Welcome to the lab, Ayo and Fanny! We look forward to working with you.
Abstract During mammalian neocortex development, nascent pyramidal neurons migrate along radial glial cells and overtake earlier-born neurons to terminate at the front of the developing cortical plate (CP), leading to the outward expansion of the CP border. While much has been learned about the cellular and molecular mechanisms that underlie the migration of pyramidal neurons, how migrating neurons bypass the preceding neurons at the end…
Please join us on Wednesday, May 4th, at 9:30 AM (Forum Hall, Palmer Commons) as the Giger lab presents the weekly CDB departmental seminar. Giger Lab members will speak on the topic below: Building, breaking down, and re-building the nervous system.
Matt, Mitre, and Karen were awarded the Rackham Graduate Student Research Grant! Congratulations to our trainees!
Neuronal injury can cause mitochondrial damage, leading to reduced energy production, decreased Ca2+ storage capacity, and increased reactive oxygen species. A new study reveals a mechanism to trigger the axonal transport of previously anchored mitochondria and promote neuroprotection and axon regeneration by replacing damaged with functional mitochondria. Check out the full article to learn more by clicking the link below! LINK: Neurobiology: Resetting the axon’s batteries…
Please join us for the defense of Lucas Huffman “More than Clearing the Clutter: The Imperative Role of Efferocytosis in Repair and Reprogramming in the Damaged Nervous System” Date: Friday, June 25, 2021 Time: 10AM EST Location: Zoom “More than Clearing the Clutter: The Imperative Role of Efferocytosis in Repair and Immune Reprogramming in the Damaged Nervous System” Dr. Roman Giger, Chair Evolutionarily, the nervous…
Mitre is a first-year graduate student in the Neuroscience Program who will be completing his thesis work in the Giger Lab. Looking forward to working with you!
